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Systematic Review

A guide on how to conduct systematic reviews in the health sciences.

What is Systematic Review?

A systematic review attempts to collate all empirical evidence that fits pre-specified eligibility criteria in order to answer a specific research question. It uses explicit, systematic methods that are selected with a view to minimizing bias, thus providing more reliable findings from which conclusions can be drawn and decisions made (Antman 1992, Oxman 1993).

The key characteristics of a systematic review

  • a clearly stated set of objectives with pre-defined eligibility criteria for studies;
  • an explicit, reproducible methodology;
  • a systematic search that attempts to identify all studies that would meet the eligibility criteria;
  • an assessment of the validity of the findings of the included studies, for example through the assessment of risk of bias; and
  • a systematic presentation, and synthesis, of the characteristics and findings of the included studies.

From Cochrane Handbook, 1.2.2

Levels of Evidence

 

Image source: EBM levels of evidence. EBM Pyramid and EBM Page Generator, © 2006 Trustees of Dartmouth College and Yale University. All Rights Reserved. Produced by Jan Glover, David Izzo, Karen Odato, and Lei Wang.